Endocrine Abstracts

We audited 46 pituitary MRI scans for patients with hypogonadotropic hypogonadism. We were particularly interested to see if adopting The Endocrine Society’s (TES) 2010 guidelines for Testosterone Therapy in Men with Androgen Deficiency Syndromes (pituitary MRIs only for those with testosterone level below 5.3 mmol/l, panhypopituitarism, persistent hyperprolactinaemia or if the patient has symptoms consistent with a mass effect such as headaches, a visual field defect or ...

Patients with Familial Hypercholesterolaemia (FH) have premature Cardiovascular disease and have a standardised mortality ratio nine times greater than normal. FH must therefore be correctly diagnosed and treated aggressively. Referral for FH is based on fulfilling the Simon Broome’s (SB) Criteria. We aimed to evaluate practice at Queen Alexandra Hospital with regards to referral for FH genetic mutation. We set out to see whether SB’s criteria were being fulfilled wh...

Introduction: Pituitary adenomas are not uncommon presentations in our clinical practice but the challenge with management becomes more daunting as the size of the tumour gets bigger as seen in this woman we present herein with a macroadenoma. The combination of factors militating against accessing the best of health care available is unconnected with the usual problems affecting health care delivery in Sub-Saharan Africa, including out-of-pocket payments for health services a...

Background: Obesity is significant risk factor for cardiovascular diseases and type 2 diabetes mellitus. Many anthropometric indexes are now being used in clinical practice to identify and determine the prevalence of obesity.Aim: This study determined the relationship between common anthropometric indexes and percentage body fat (%BF).Methodology: Ninety-four volunteer subjects participated in this cross sectional hospital based st...

Introduction: Bilateral adrenal haemorrhage is a rare potentially life-threatening event that occurs either in traumatic or non traumatic conditions. We present a rare case report of bilateral adrenal haemorrhage due to anti-phospholipid antibody syndrome.Case report: A 54 year old Iranian origin male presented with abdominal pain and collapse. His past history includes unprovoked DVT 6 months ago and off the warfarin recently. CT abdomen showed bilatera...

Introduction: The measurement of free thyroxine (FT4) and free 3,3′,5-triiodothyronine (FT3) in serum by equilibrium dialysis immunoassay methods may suffer from a lack of specificity, therefore measurement by LC/MS/MS has the potential to increase the accuracy of the results. Here we present a sensitive method, employing a simple ultrafiltration sample preparation.Description of methods: 400 uL of serum were processed for 90 minutes using a 3kDa c...

Hypercalcemia in hyperthyroidism is usually asymptomatic, and related to a concurrent primary hyperparathyroidism. In this report, we describe a case of symptomatic hypercalcemia secondary to Graves’ disease alone.Case report: A 24-year-old Filipino female presented to the emergency department with generalized weakness, vomiting and abdominal pain. No other symptoms were noted. She was otherwise previously healthy. Family history was unremarkable. ...

Background: A reliable form of androgen substitution therapy in terms of favorable kinetics and tolerance as well as effective restoration of androgenicity is paramount for hypogonadal men. The i.m. injection of the long-acting ester testosterone undecanoate (TU) offers a convenient modality for testosterone substitution.Methods: We report data from 334 patients (147 with primary (including 38 Klinefelter patients), 100 with secondary hypogonadism and 87...

Introduction: Primary hyperparathyroidism (PHPT) can only be cured by parathyroidectomy (PTX) but mild and asymptomatic cases can often be managed conservatively. We carried out a retrospective audit of patients attending the Endocrine clinic at Watford to determine how our practice compared with the different guidelines for surgical referral published in the USA and the UK.Method: A search was carried out of clinic letters from Jan 2010 to Oct 2011. Add...

IVF and ICSI are fully established methods of assisted reproduction which can be used for patients awaiting cytotoxic therapy:Following the data of the German, Swiss and Austrian network Fertiprotekt (www.fertiprotekt.eu), 164 of 1388 counselled patients have chosen ovarian stimulation and cryopreservation of oocytes as a fertility preservation technique in 2007–2009. Among those patients 2417 oocytes were co...